Association between drug treatments and the incidence of liver injury in hospitalized patients with COVID-19

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Before Pharmacol. 2022 Mar 21;13:799338. doi: 10.3389/fphar.2022.799338. eCollection 2022.

ABSTRACT

The outbreak of coronavirus disease 2019 (COVID-19) has led to the emergence of global healthcare. In this study, we sought to explore the association between drug treatments and the incidence of drug-induced liver injury (DILI) in hospitalized patients with COVID-19. A retrospective study was conducted on 5,113 COVID-19 patients in Hubei Province, of whom 395 suffered liver damage. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated by Cox proportional hazards models. The results showed that COVID-19 patients who received antibiotics (HR 1.97, 95% CI: 1.55-2.51, p p 0.001) and corticosteroids (HR 2.31, 95% CI: 1.80-2.96, p p p

PMID:35387350 | CPM:PMC8978013 | DO I:10.3389/fphar.2022.799338

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